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Oral Prion Neuroinvasion Occurs Independently of PrP(C) Expression in the Gut Epithelium
The early replication of certain prion strains within Peyer's patches in the small intestine is essential for the efficient spread of disease to the brain after oral exposure. Our data show that orally acquired prions utilize specialized gut epithelial cells known as M cells to enter Peyer'...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146811/ https://www.ncbi.nlm.nih.gov/pubmed/30021891 http://dx.doi.org/10.1128/JVI.01010-18 |