Marked Global DNA Hypomethylation Is Associated with Constitutive PD-L1 Expression in Melanoma

Constitutive expression of the immune checkpoint, PD-L1, inhibits anti-tumor immune responses in cancer, although the factors involved in PD-L1 regulation are poorly understood. Here we show that loss of global DNA methylation, particularly in intergenic regions and repeat elements, is associated wi...

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Detalles Bibliográficos
Autores principales: Chatterjee, Aniruddha, Rodger, Euan J., Ahn, Antonio, Stockwell, Peter A., Parry, Matthew, Motwani, Jyoti, Gallagher, Stuart J., Shklovskaya, Elena, Tiffen, Jessamy, Eccles, Michael R., Hersey, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147024/
https://www.ncbi.nlm.nih.gov/pubmed/30240750
http://dx.doi.org/10.1016/j.isci.2018.05.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147024/
https://www.ncbi.nlm.nih.gov/pubmed/30240750
http://dx.doi.org/10.1016/j.isci.2018.05.021

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