Mutant and Wild-Type Tumor Suppressor p53 Induces p300 Autoacetylation

The transcriptional co-activator p300 is essential for p53 transactivation, although its precise role remains unclear. We report that p53 activates the acetyltransferase activity of p300 through the enhancement of p300 autoacetylation. Autoacetylated p300 accumulates near the transcription start sit...

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Detalles Bibliográficos
Autores principales: Kaypee, Stephanie, Sahadevan, Smitha Asoka, Patil, Shilpa, Ghosh, Piya, Roy, Neeladri Sekhar, Roy, Siddhartha, Kundu, Tapas K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147029/
https://www.ncbi.nlm.nih.gov/pubmed/30240745
http://dx.doi.org/10.1016/j.isci.2018.06.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147029/
https://www.ncbi.nlm.nih.gov/pubmed/30240745
http://dx.doi.org/10.1016/j.isci.2018.06.002

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