Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design

Several bacteria rely on the reductive sulphur assimilation pathway, absent in mammals, to synthesise cysteine. Reduction of virulence and decrease in antibiotic resistance have already been associated with mutations on the genes that codify cysteine biosynthetic enzymes. Therefore, inhibition of cy...

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Detalles Bibliográficos
Autores principales: Magalhães, Joana, Franko, Nina, Annunziato, Giannamaria, Welch, Martin, Dolan, Stephen K., Bruno, Agostino, Mozzarelli, Andrea, Armao, Stefano, Jirgensons, Aigars, Pieroni, Marco, Costantino, Gabriele, Campanini, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147075/
https://www.ncbi.nlm.nih.gov/pubmed/30221554
http://dx.doi.org/10.1080/14756366.2018.1512596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147075/
https://www.ncbi.nlm.nih.gov/pubmed/30221554
http://dx.doi.org/10.1080/14756366.2018.1512596

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