The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins

Type I interferon (IFN)-stimulated genes (ISGs) have critical roles in inhibiting virus replication and dissemination. Despite advances in understanding the molecular basis of ISG restriction, the antiviral mechanisms of many remain unclear. The 20-kDa ISG ISG20 is a nuclear 3′–5′ exonuclease with p...

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Detalles Bibliográficos
Autores principales: Weiss, Christopher M., Trobaugh, Derek W., Sun, Chengqun, Lucas, Tiffany M., Diamond, Michael S., Ryman, Kate D., Klimstra, William B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147134/
https://www.ncbi.nlm.nih.gov/pubmed/30232164
http://dx.doi.org/10.1128/mSphere.00209-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147134/
https://www.ncbi.nlm.nih.gov/pubmed/30232164
http://dx.doi.org/10.1128/mSphere.00209-18

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