The estrogen metabolite 2-methoxyestradiol regulates eukaryotic initiation factor 4E (eIF4E) and inhibits protein synthesis in MG63 osteosarcoma cells

Osteosarcoma is a primary bone tumor that affects children and young adults. The estrogen metabolite 2-methoxyestradiol (2-ME) induces cell death in osteosarcoma cells. To determine whether 2-ME actions involve the control of protein synthesis, we studied the effect of 2-ME on eukaryotic initiation...

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Detalles Bibliográficos
Autores principales: Maran, Avudaiappan, Shogren, Kristen L., Yaszemski, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147162/
https://www.ncbi.nlm.nih.gov/pubmed/30258883
http://dx.doi.org/10.1016/j.gendis.2016.04.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147162/
https://www.ncbi.nlm.nih.gov/pubmed/30258883
http://dx.doi.org/10.1016/j.gendis.2016.04.001

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