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Current understanding and dispute on the function of the Wnt signaling pathway effector TCF7L2 in hepatic gluconeogenesis
Approximately 10 years ago, the Wnt signaling pathway effector TCF7L2 (=TCF-4) was recognized as a type 2 diabetes (T2D) risk gene through a genome wide association study (GWAS). As the correlation between TCF7L2 polymorphisms and T2D susceptibility has been reproducibly observed by numerous follow-...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Chongqing Medical University
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147171/ https://www.ncbi.nlm.nih.gov/pubmed/30258876 http://dx.doi.org/10.1016/j.gendis.2015.10.002 |