A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity

Many xenobiotics can bind to off-target receptors and cause toxicity via the dysregulation of downstream transcription factors. Identification of subsequent off-target toxicity in these chemicals has often required extensive chemical testing in animal models. An alternative, integrated in vitro/in s...

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Detalles Bibliográficos
Autores principales: Leedale, Joseph, Sharkey, Kieran J., Colley, Helen E., Norton, Áine M., Peeney, David, Mason, Chantelle L., Sathish, Jean G., Murdoch, Craig, Sharma, Parveen, Webb, Steven D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147237/
https://www.ncbi.nlm.nih.gov/pubmed/30240756
http://dx.doi.org/10.1016/j.isci.2018.05.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147237/
https://www.ncbi.nlm.nih.gov/pubmed/30240756
http://dx.doi.org/10.1016/j.isci.2018.05.012

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