Towards a Synthesis of Vigabatrin Using Glycal Chemistry

Application of the Ferrier rearrangement led to a novel carbohydrate based synthetic route to 4-aminohexenoic acid viz. (R) and (S)-vigabatrin. The potential of D- glucose or D-galactose as the chiral starting materials for the synthesis of (R) and (S)- vigabatrin has been explored.

Detalles Bibliográficos
Autores principales: Boga, Sobhana B., Aidhen, Jaimala S., Aidhen, Indrapal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147543/
https://www.ncbi.nlm.nih.gov/pubmed/18007356
http://dx.doi.org/10.3390/10080871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147543/
https://www.ncbi.nlm.nih.gov/pubmed/18007356
http://dx.doi.org/10.3390/10080871

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