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Progranulin Deficient Mice Develop Nephrogenic Diabetes Insipidus
Loss-of-function mutations of progranulin are associated with frontotemporal dementia in humans, and its deficiency in mice is a model for this disease but with normal life expectancy and mild cognitive decline on aging. The present study shows that aging progranulin deficient mice develop progressi...
Autores principales: | Hardt, Stefanie, Valek, Lucie, Zeng-Brouwers, Jinyang, Wilken-Schmitz, Annett, Schaefer, Liliana, Tegeder, Irmgard |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JKL International LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147595/ https://www.ncbi.nlm.nih.gov/pubmed/30271659 http://dx.doi.org/10.14336/AD.2017.1127 |
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