Prions activate a p38 MAPK synaptotoxic signaling pathway

Synaptic degeneration is one of the earliest pathological correlates of prion disease, and it is a major determinant of the progression of clinical symptoms. However, the cellular and molecular mechanisms underlying prion synaptotoxicity are poorly understood. Previously, we described an experimenta...

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Detalles Bibliográficos
Autores principales: Fang, Cheng, Wu, Bei, Le, Nhat T. T., Imberdis, Thibaut, Mercer, Robert C. C., Harris, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147624/
https://www.ncbi.nlm.nih.gov/pubmed/30235355
http://dx.doi.org/10.1371/journal.ppat.1007283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147624/
https://www.ncbi.nlm.nih.gov/pubmed/30235355
http://dx.doi.org/10.1371/journal.ppat.1007283

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