Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones

Three convenient methods of reduction of the nitro group of 5-nitroimidazoles and 5-nitrothiazole that bear a diethylmethylene malonate group in an ortho-like position with respect to the nitro group and cyclization of the resulting amino derivatives are reported. These reactions afforded the target...

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Autores principales: Crozet, Maxime D., George, Pascal, Crozet, Michel P., Vanelle, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147647/
https://www.ncbi.nlm.nih.gov/pubmed/18007525
http://dx.doi.org/10.3390/10101318
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author Crozet, Maxime D.
George, Pascal
Crozet, Michel P.
Vanelle, Patrice
author_facet Crozet, Maxime D.
George, Pascal
Crozet, Michel P.
Vanelle, Patrice
author_sort Crozet, Maxime D.
collection PubMed
description Three convenient methods of reduction of the nitro group of 5-nitroimidazoles and 5-nitrothiazole that bear a diethylmethylene malonate group in an ortho-like position with respect to the nitro group and cyclization of the resulting amino derivatives are reported. These reactions afforded the target bicyclic 2-pyridones in good to excellent yields.
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spelling pubmed-61476472018-11-16 Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones Crozet, Maxime D. George, Pascal Crozet, Michel P. Vanelle, Patrice Molecules Article Three convenient methods of reduction of the nitro group of 5-nitroimidazoles and 5-nitrothiazole that bear a diethylmethylene malonate group in an ortho-like position with respect to the nitro group and cyclization of the resulting amino derivatives are reported. These reactions afforded the target bicyclic 2-pyridones in good to excellent yields. MDPI 2005-10-31 /pmc/articles/PMC6147647/ /pubmed/18007525 http://dx.doi.org/10.3390/10101318 Text en © 2005 by MDPI (http:www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Crozet, Maxime D.
George, Pascal
Crozet, Michel P.
Vanelle, Patrice
Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones
title Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones
title_full Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones
title_fullStr Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones
title_full_unstemmed Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones
title_short Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones
title_sort synthesis of new potentially bioactive bicyclic 2-pyridones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147647/
https://www.ncbi.nlm.nih.gov/pubmed/18007525
http://dx.doi.org/10.3390/10101318
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AT georgepascal synthesisofnewpotentiallybioactivebicyclic2pyridones
AT crozetmichelp synthesisofnewpotentiallybioactivebicyclic2pyridones
AT vanellepatrice synthesisofnewpotentiallybioactivebicyclic2pyridones

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