Cargando…

Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones

Three convenient methods of reduction of the nitro group of 5-nitroimidazoles and 5-nitrothiazole that bear a diethylmethylene malonate group in an ortho-like position with respect to the nitro group and cyclization of the resulting amino derivatives are reported. These reactions afforded the target...

Descripción completa

Detalles Bibliográficos
Autores principales:	Crozet, Maxime D., George, Pascal, Crozet, Michel P., Vanelle, Patrice
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147647/ https://www.ncbi.nlm.nih.gov/pubmed/18007525 http://dx.doi.org/10.3390/10101318

Ejemplares similares

Synthesis and Promising in Vitro Antiproliferative Activity of Sulfones of a 5-Nitrothiazole Series
por: Cohen, Anita, et al.
Publicado: (2012)

High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach
por: Juspin, Thierry, et al.
Publicado: (2011)

An Efficient One-Pot Catalyzed Synthesis of 2,4-Disubstituted 5-Nitroimidazoles Displaying Antiparasitic and Antibacterial Activities
por: Mathias, Fanny, et al.
Publicado: (2017)

A Practical Approach to Bicyclic Carbamoyl Pyridones with Application to the Synthesis of HIV-1 Integrase Strand Transfer Inhibitors
por: Mahajan, Pankaj S., et al.
Publicado: (2023)

Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors
por: Kulén, Martina, et al.
Publicado: (2019)

Synthesis of 4-Pyridone-3-sulfate and an improved synthesis of 3-Hydroxy-4-Pyridone
por: Behrman, Edward J
Publicado: (2009)

Bioactive 2-pyridone-containing heterocycle syntheses using multicomponent reactions
por: Hurtado-Rodríguez, Diana, et al.
Publicado: (2022)

Practical and Metal-Free Synthesis of Novel Enantiopure Amides Containing the Potentially Bioactive 5-Nitroimidazole Moiety
por: Spitz, Cédric, et al.
Publicado: (2016)

2-Pyridone: monoclinic polymorph
por: Arman, Hadi D., et al.
Publicado: (2009)

Emerging roles and mechanisms of ERK pathway mechanosensing
por: Crozet, Flora, et al.
Publicado: (2023)

5-Methyl-2-pyridone
por: Mao, Shulin, et al.
Publicado: (2011)

Synthesis and Biological Evaluation of New Pyridone-Annelated Isoindigos as Anti-Proliferative Agents
por: Saleh, Ayman M., et al.
Publicado: (2014)

International Trade and Letters of Credit: A Double-Edged Sword in Times of Crises
por: Crozet, Matthieu, et al.
Publicado: (2022)

One-pot two-step catalytic synthesis of 6-amino-2-pyridone-3,5-dicarbonitriles enabling anti-cancer bioactivity
por: Nicely, Lynden G., et al.
Publicado: (2022)

Synthesis of New Active Sulfones in the 5-Nitroimidazole Series
por: Benakli, Kamel, et al.
Publicado: (2002)

New Pyridone-Based Derivatives as Cannabinoid Receptor Type 2 Agonists
por: Faúndez-Parraguez, Manuel, et al.
Publicado: (2021)

Efficient and divergent synthesis of polyfunctionalized 2-pyridones from β-keto amides
por: Gao, Baochang, et al.
Publicado: (2018)

Diversity-oriented functionalization of 2-pyridones and uracils
por: Shang, Yong, et al.
Publicado: (2021)

Synthesis of 3-Alkenyl-1-azaanthraquinones via Diels-Alder and Electron Transfer Reactions
por: Rathelot, Pascal, et al.
Publicado: (2002)

New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate
por: Bouhlel, Ahlem, et al.
Publicado: (2012)

catena-Poly[[[(2-pyridone-κO)silver(I)]-μ-2-pyridone-κ(2) O:O] hexafluoridophosphate]
por: Arman, Hadi D., et al.
Publicado: (2010)

Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp. UJNMF0008
por: Bao, Jie, et al.
Publicado: (2018)

The Biochemical Pathways of Nicotinamide-Derived Pyridones
por: Hayat, Faisal, et al.
Publicado: (2021)

Synthesis and Phytotoxic Activity of New Pyridones Derived from 4-Hydroxy-6-Methylpyridin-2(1H)-one
por: Jacinto Demuner, Antonio, et al.
Publicado: (2009)

High-Resolution Crystal Structure of Chloroplastic Ribose-5-Phosphate Isomerase from Chlamydomonas reinhardtii—An Enzyme Involved in the Photosynthetic Calvin-Benson Cycle
por: Le Moigne, Théo, et al.
Publicado: (2020)

Design, Synthesis, and Phenotypic Profiling of Pyrano‐Furo‐Pyridone Pseudo Natural Products
por: Christoforow, Andreas, et al.
Publicado: (2019)

Umpolung Synthesis of Pyridyl Ethers by Bi(V)‐Mediated O‐Arylation of Pyridones
por: Ruffell, Katie, et al.
Publicado: (2022)

Blasticidin S Deaminase: A New Efficient Selectable Marker for Chlamydomonas reinhardtii
por: de Carpentier, Félix, et al.
Publicado: (2020)

Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators
por: Zhang, Xujie, et al.
Publicado: (2022)

Synthesis and Decarboxylation of Functionalized 2-Pyridone-3-carboxylic Acids and Evaluation of their Antimicrobial Activity and Molecular Docking
por: Meghrazi Ahadi, Elmira, et al.
Publicado: (2021)

Design, Synthesis, and Antimicrobial Evaluation of a New Series of N-Sulfonamide 2-Pyridones as Dual Inhibitors of DHPS and DHFR Enzymes
por: Azzam, Rasha A., et al.
Publicado: (2020)

Novel Synthesis and Antiviral Evaluation of New Benzothiazole-Bearing N-Sulfonamide 2-Pyridone Derivatives as USP7 Enzyme Inhibitors
por: Azzam, Rasha A., et al.
Publicado: (2020)

Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones
por: Tyagi, Mohit, et al.
Publicado: (2021)

Design, Synthesis, and Evaluation of Novel Δ(2)-Thiazolino 2-Pyridone Derivatives That Potentiate Isoniazid Activity in an Isoniazid-Resistant Mycobacterium tuberculosis Mutant
por: Sarkar, Souvik, et al.
Publicado: (2023)

Synthesis of a Pyridone-Based Phthalimide Fleximer and Its Characterization and Supramolecular Property Evaluation
por: Dowarah, Jayanta, et al.
Publicado: (2022)

2-Ethyl-3-hydroxy-1-isopropyl-4-pyridone
por: Molokoane, Pule P., et al.
Publicado: (2012)

Crystal structure of 2,6-dimethyl-4-pyridone hemihydrate
por: Nguyen, Dalena M., et al.
Publicado: (2015)

6-Halo-2-pyridone as an efficient organocatalyst for ester aminolysis
por: Yamada, Takeshi, et al.
Publicado: (2021)

Crystal Structure of Chloroplastic Thioredoxin f2 from Chlamydomonas reinhardtii Reveals Distinct Surface Properties
por: Lemaire, Stéphane D., et al.
Publicado: (2018)

Myosin-X is dispensable for spindle morphogenesis and positioning in the mouse oocyte
por: Crozet, Flora, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_b9rd2e2s0ftenifu5lk3f2b4tp