Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling

A mutated KRAS protein is frequently observed in human cancers. Traditionally, the oncogenic properties of KRAS missense mutants at position 12 (G12X) have been considered as equal. Here, by assessing the probabilities of occurrence of all KRAS G12X mutations and KRAS dynamics we show that this assu...

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Detalles Bibliográficos
Autores principales: Pantsar, Tatu, Rissanen, Sami, Dauch, Daniel, Laitinen, Tuomo, Vattulainen, Ilpo, Poso, Antti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147662/
https://www.ncbi.nlm.nih.gov/pubmed/30199525
http://dx.doi.org/10.1371/journal.pcbi.1006458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147662/
https://www.ncbi.nlm.nih.gov/pubmed/30199525
http://dx.doi.org/10.1371/journal.pcbi.1006458

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