Microwave-Assisted Amination of a Chloropurine Derivative in the Synthesis of Acyclic Nucleoside Analogues

An efficient protocol for the amination of 6-chloropurine derivatives through nucleophilic aromatic substitution under microwave irradiation was developed and applied to the synthesis in two steps of a series of new acyclic nucleosides (acyclovir analogues) starting from commercially available compo...

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Detalles Bibliográficos
Autores principales: Lanver, Andreas, Schmalz, Hans-Günther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147686/
https://www.ncbi.nlm.nih.gov/pubmed/18007322
http://dx.doi.org/10.3390/10020508
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author Lanver, Andreas
Schmalz, Hans-Günther
author_facet Lanver, Andreas
Schmalz, Hans-Günther
author_sort Lanver, Andreas
collection PubMed
description An efficient protocol for the amination of 6-chloropurine derivatives through nucleophilic aromatic substitution under microwave irradiation was developed and applied to the synthesis in two steps of a series of new acyclic nucleosides (acyclovir analogues) starting from commercially available compounds.
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spelling pubmed-61476862018-11-19 Microwave-Assisted Amination of a Chloropurine Derivative in the Synthesis of Acyclic Nucleoside Analogues Lanver, Andreas Schmalz, Hans-Günther Molecules Article An efficient protocol for the amination of 6-chloropurine derivatives through nucleophilic aromatic substitution under microwave irradiation was developed and applied to the synthesis in two steps of a series of new acyclic nucleosides (acyclovir analogues) starting from commercially available compounds. MDPI 2005-02-28 /pmc/articles/PMC6147686/ /pubmed/18007322 http://dx.doi.org/10.3390/10020508 Text en © 2005 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Lanver, Andreas
Schmalz, Hans-Günther
Microwave-Assisted Amination of a Chloropurine Derivative in the Synthesis of Acyclic Nucleoside Analogues
title Microwave-Assisted Amination of a Chloropurine Derivative in the Synthesis of Acyclic Nucleoside Analogues
title_full Microwave-Assisted Amination of a Chloropurine Derivative in the Synthesis of Acyclic Nucleoside Analogues
title_fullStr Microwave-Assisted Amination of a Chloropurine Derivative in the Synthesis of Acyclic Nucleoside Analogues
title_full_unstemmed Microwave-Assisted Amination of a Chloropurine Derivative in the Synthesis of Acyclic Nucleoside Analogues
title_short Microwave-Assisted Amination of a Chloropurine Derivative in the Synthesis of Acyclic Nucleoside Analogues
title_sort microwave-assisted amination of a chloropurine derivative in the synthesis of acyclic nucleoside analogues
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147686/
https://www.ncbi.nlm.nih.gov/pubmed/18007322
http://dx.doi.org/10.3390/10020508
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AT schmalzhansgunther microwaveassistedaminationofachloropurinederivativeinthesynthesisofacyclicnucleosideanalogues

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