Arsenic circumvents the gefitinib resistance by binding to P62 and mediating autophagic degradation of EGFR in non-small cell lung cancer

Non-small cell lung cancer (NSCLC) is characterized by hyperexpression and/or gain-of-function mutations of the epidermal growth factor receptor (EGFR), resulting in an elevated overall kinase activity. Gefitinib is remarkably effective in patients with the L858R or ΔE746-A750-mutated of EGFR. Howev...

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Detalles Bibliográficos
Autores principales: Mao, Jianhua, Ma, Lie, Shen, Yan, Zhu, Kongkai, Zhang, Ru, Xi, Wenda, Ruan, Zheng, Luo, Cheng, Chen, Zhu, Xi, Xiaodong, Chen, Saijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147786/
https://www.ncbi.nlm.nih.gov/pubmed/30237564
http://dx.doi.org/10.1038/s41419-018-0998-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147786/
https://www.ncbi.nlm.nih.gov/pubmed/30237564
http://dx.doi.org/10.1038/s41419-018-0998-7

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