Cargando…

Arsenic circumvents the gefitinib resistance by binding to P62 and mediating autophagic degradation of EGFR in non-small cell lung cancer

Non-small cell lung cancer (NSCLC) is characterized by hyperexpression and/or gain-of-function mutations of the epidermal growth factor receptor (EGFR), resulting in an elevated overall kinase activity. Gefitinib is remarkably effective in patients with the L858R or ΔE746-A750-mutated of EGFR. Howev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mao, Jianhua, Ma, Lie, Shen, Yan, Zhu, Kongkai, Zhang, Ru, Xi, Wenda, Ruan, Zheng, Luo, Cheng, Chen, Zhu, Xi, Xiaodong, Chen, Saijuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147786/ https://www.ncbi.nlm.nih.gov/pubmed/30237564 http://dx.doi.org/10.1038/s41419-018-0998-7

Ejemplares similares

Author Correction: Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells
por: Wang, Yue-qin, et al.
Publicado: (2020)

miR-4487 Enhances Gefitinib-Mediated Ubiquitination and Autophagic Degradation of EGFR in Non–Small Cell Lung Cancer Cells by Targeting USP37
por: Kim, Mi Seong, et al.
Publicado: (2022)

Enhanced p62-NRF2 Feedback Loop due to Impaired Autophagic Flux Contributes to Arsenic-Induced Malignant Transformation of Human Keratinocytes
por: Wu, Xiafang, et al.
Publicado: (2019)

EGFR enhances the stemness and progression of oral cancer through inhibiting autophagic degradation of SOX2
por: Lv, Xiao‐Xi, et al.
Publicado: (2019)

TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations
por: Hua, Fang, et al.
Publicado: (2015)

ATNC: Versatile Nanobody Chimeras for Autophagic Degradation of Intracellular Unligandable and Undruggable Proteins
por: He, Huiping, et al.
Publicado: (2023)

Autophagic Regulation of p62 is Critical for Cancer Therapy
por: Islam, Md. Ariful, et al.
Publicado: (2018)

Matching Mitochondrial DNA Haplotypes for Circumventing Tissue-Specific Segregation Bias
por: Pan, Jianxin, et al.
Publicado: (2019)

Copper-dependent autophagic degradation of GPX4 drives ferroptosis
por: Xue, Qian, et al.
Publicado: (2023)

Curcumin Induces EGFR Degradation in Lung Adenocarcinoma and Modulates p38 Activation in Intestine: The Versatile Adjuvant for Gefitinib Therapy
por: Lee, Jen-Yi, et al.
Publicado: (2011)

TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10
por: Tan, Peng, et al.
Publicado: (2018)

Autophagy Activation Induces p62-Dependent Autophagic Degradation of Dengue Virus Capsid Protein During Infection
por: Wu, Yaoxing, et al.
Publicado: (2022)

Arsenic Inhibits Proliferation and Induces Autophagy of Tumor Cells in Pleural Effusion of Patients with Non-Small Cell Lung Cancer Expressing EGFR with or without Mutations via PI3K/AKT/mTOR Pathway
por: Mao, Jianhua, et al.
Publicado: (2023)

Circumventing the Greatwall
por: Short, Ben
Publicado: (2014)

Cytoplasmic Cargo Receptor p62 Inhibits Avibirnavirus Replication by Mediating Autophagic Degradation of Viral Protein VP2
por: Li, Yahui, et al.
Publicado: (2020)

Central nervous system progression in advanced non–small cell lung cancer patients with EGFR mutations in response to first-line treatment with two EGFR-TKIs, gefitinib and erlotinib: a comparative study
por: Li, Meng-Xia, et al.
Publicado: (2017)

Lack of EGFR mutations benefiting gefitinib treatment in adenocarcinoma of esophagogastric junction
por: Wang, Wen-Ping, et al.
Publicado: (2012)

Autophagic degradation of the endoplasmic reticulum
por: NAKATOGAWA, Hitoshi
Publicado: (2020)

Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis
por: Mao, Jianhua, et al.
Publicado: (2022)

Cost-Effectiveness Analysis of Gefitinib Plus Chemotherapy versus Gefitinib Alone for Advanced Non-Small-Cell Lung Cancer with EGFR Mutations in China
por: Shu, Yamin, et al.
Publicado: (2021)

Activity of pemetrexed and high-dose gefitinib in an EGFR-mutated lung adenocarcinoma with brain and leptomeningeal metastasis after response to gefitinib
por: Yuan, Ying, et al.
Publicado: (2012)

Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation
por: Wang, Siliang, et al.
Publicado: (2020)

Cancer-associated fibroblasts-derived CXCL12 enhances immune escape of bladder cancer through inhibiting P62-mediated autophagic degradation of PDL1
por: Zhang, Zhao, et al.
Publicado: (2023)

Acquired Gefitinib-Resistant Mutation of EGFR in a Chemonaive Lung Adenocarcinoma Harboring Gefitinib-Sensitive Mutation L858R
por: Gow, Chien-Hung, et al.
Publicado: (2005)

Role of Endocytosis Proteins in Gefitinib-Mediated EGFR Internalisation in Glioma Cells
por: Cruz Da Silva, Elisabete, et al.
Publicado: (2021)

The hypertension drug, verapamil, activates Nrf2 by promoting p62-dependent autophagic Keap1 degradation and prevents acetaminophen-induced cytotoxicity
por: Lee, Da Hyun, et al.
Publicado: (2017)

Poly C Binding Protein 1 Regulates p62/SQSTM1 mRNA Stability and Autophagic Degradation to Repress Tumor Progression
por: Zhang, Wenliang, et al.
Publicado: (2020)

Neferine promotes the apoptosis of HNSCC through the accumulation of p62/SQSTM1 caused by autophagic flux inhibition
por: Zhu, Fengshuo, et al.
Publicado: (2021)

Docosahexaenoic Acid Serving As Sensitizing Agents And Gefitinib Resistance Revertants In EGFR Targeting Treatment
por: Ding, Xuansheng, et al.
Publicado: (2019)

Arsenic trioxide induces autophagic degradation of the FLT3-ITD mutated protein in FLT3-ITD acute myeloid leukemia cells
por: Liu, Xiao-Jian, et al.
Publicado: (2020)

Advantages and Limitations of Different p62-Based Assays for Estimating Autophagic Activity in Drosophila
por: Pircs, Karolina, et al.
Publicado: (2012)

Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation
por: Sun, Daxiao, et al.
Publicado: (2018)

Autophagic receptor p62 protects against glycation‐derived toxicity and enhances viability
por: Aragonès, Gemma, et al.
Publicado: (2020)

The Dissociation of Gefitinib Trough Concentration and Clinical Outcome in NSCLC Patients with EGFR Sensitive Mutations
por: Xin, Shuang, et al.
Publicado: (2015)

Updated Analysis of NEJ009: Gefitinib-Alone Versus Gefitinib Plus Chemotherapy for Non–Small-Cell Lung Cancer With Mutated EGFR
por: Miyauchi, Eisaku, et al.
Publicado: (2022)

TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the β-catenin/ABCC9 axis via p62-selective autophagic degradation of Daple
por: Zhang, Runa, et al.
Publicado: (2020)

Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII
por: Pedersen, M W, et al.
Publicado: (2005)

Shikonin sensitizes wild-type EGFR NSCLC cells to erlotinib and gefitinib therapy
por: Li, Yang-Ling, et al.
Publicado: (2018)

The Effect of Gefitinib on Treatment Necessity and Prognosis of NSCLC Patients with Early EGFR Mutations
por: Song, Ruiqiang, et al.
Publicado: (2022)

Pathway choice between proteasomal and autophagic degradation
por: Lu, Kefeng, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_toi0ejidpdbnj5ljkte15friv2