mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy

mTOR is an important regulator of cell growth and forms two complexes, mTORC1/2. In cancer, mTOR signaling is highly activated, and the regulation of this signaling, as an anti-cancer strategy, has been emphasized. However, PP242 (inhibitor of mTORC1 and mTORC2) alone did not induce human renal carc...

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Detalles Bibliográficos
Autores principales: Seo, Seung Un, Woo, Seon Min, Lee, Hyun-Shik, Kim, Sang Hyun, Min, Kyoung-jin, Kwon, Taeg Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147804/
https://www.ncbi.nlm.nih.gov/pubmed/29849119
http://dx.doi.org/10.1038/s41388-018-0345-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147804/
https://www.ncbi.nlm.nih.gov/pubmed/29849119
http://dx.doi.org/10.1038/s41388-018-0345-6

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