Bi-directional genetic modulation of GSK-3β exacerbates hippocampal neuropathology in experimental status epilepticus

Glycogen synthase kinase-3 (GSK-3) is ubiquitously expressed throughout the brain and involved in vital molecular pathways such as cell survival and synaptic reorganization and has emerged as a potential drug target for brain diseases. A causal role for GSK-3, in particular the brain-enriched GSK-3β...

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Detalles Bibliográficos
Autores principales: Engel, Tobias, Gómez-Sintes, Raquel, Alves, Mariana, Jimenez-Mateos, Eva M., Fernández-Nogales, Marta, Sanz-Rodriguez, Amaya, Morgan, James, Beamer, Edward, Rodríguez-Matellán, Alberto, Dunleavy, Mark, Sano, Takanori, Avila, Jesus, Medina, Miguel, Hernandez, Felix, Lucas, José J., Henshall, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147910/
https://www.ncbi.nlm.nih.gov/pubmed/30237424
http://dx.doi.org/10.1038/s41419-018-0963-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147910/
https://www.ncbi.nlm.nih.gov/pubmed/30237424
http://dx.doi.org/10.1038/s41419-018-0963-5

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