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The association of plasma homocysteine levels with serum leptin and apolipoprotein B levels in childhood obesity

BACKGROUND: An elevated plasma total homocysteine (tHcy) level has recently been established as an independent risk factor for thrombosis and vascular disease. However, the relationship between hyperhomocysteinemia and cardiovascular disease and obesity remains controversial. The aim of the study wa...

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Autores principales: Narin, Figen, Atabek, Mehmet Emre, Karakukcu, Musa, Narin, Nazmi, Kurtoglu, Selim, Gumus, Hakan, Çoksevim, Bekir, Erez, Rusen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147986/
https://www.ncbi.nlm.nih.gov/pubmed/16119521
http://dx.doi.org/10.5144/0256-4947.2005.209
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author Narin, Figen
Atabek, Mehmet Emre
Karakukcu, Musa
Narin, Nazmi
Kurtoglu, Selim
Gumus, Hakan
Çoksevim, Bekir
Erez, Rusen
author_facet Narin, Figen
Atabek, Mehmet Emre
Karakukcu, Musa
Narin, Nazmi
Kurtoglu, Selim
Gumus, Hakan
Çoksevim, Bekir
Erez, Rusen
author_sort Narin, Figen
collection PubMed
description BACKGROUND: An elevated plasma total homocysteine (tHcy) level has recently been established as an independent risk factor for thrombosis and vascular disease. However, the relationship between hyperhomocysteinemia and cardiovascular disease and obesity remains controversial. The aim of the study was to investigate a possible relationship between plasma tHcy levels and measures of childhood obesity. SUBJECTS AND METHODS: Forty children and adolescents with exogenous obesity and 20 non-obese subjects in an age-and sex-matched control group were investigated. Fasting samples were collected for plasma tHcy, serum insulin, leptin, vitamin B12, folate, creatinine and lipid parameters. Anthropometric characteristics and body compositions were assessed in both groups. RESULTS: The obese patients had significantly higher tHcy levels than the non-obese controls (14.3±11.8 μmol/L vs 8.7±5.9 μmol/L; P=0.017). In both groups, plasma tHcy was positively related to serum leptin, but serum apolipoprotein B (apo B) levels were positively related to plasma tHcy levels only in obese patients. CONCLUSIONS: Our study demonstrates for the first time that leptin and apo B are main correlates of tHcy in obese children and adolescents and suggests that hyperleptinemia and increased apo B may contribute to impairment of tHcy metabolism in childhood obesity.
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spelling pubmed-61479862018-09-21 The association of plasma homocysteine levels with serum leptin and apolipoprotein B levels in childhood obesity Narin, Figen Atabek, Mehmet Emre Karakukcu, Musa Narin, Nazmi Kurtoglu, Selim Gumus, Hakan Çoksevim, Bekir Erez, Rusen Ann Saudi Med Original Article BACKGROUND: An elevated plasma total homocysteine (tHcy) level has recently been established as an independent risk factor for thrombosis and vascular disease. However, the relationship between hyperhomocysteinemia and cardiovascular disease and obesity remains controversial. The aim of the study was to investigate a possible relationship between plasma tHcy levels and measures of childhood obesity. SUBJECTS AND METHODS: Forty children and adolescents with exogenous obesity and 20 non-obese subjects in an age-and sex-matched control group were investigated. Fasting samples were collected for plasma tHcy, serum insulin, leptin, vitamin B12, folate, creatinine and lipid parameters. Anthropometric characteristics and body compositions were assessed in both groups. RESULTS: The obese patients had significantly higher tHcy levels than the non-obese controls (14.3±11.8 μmol/L vs 8.7±5.9 μmol/L; P=0.017). In both groups, plasma tHcy was positively related to serum leptin, but serum apolipoprotein B (apo B) levels were positively related to plasma tHcy levels only in obese patients. CONCLUSIONS: Our study demonstrates for the first time that leptin and apo B are main correlates of tHcy in obese children and adolescents and suggests that hyperleptinemia and increased apo B may contribute to impairment of tHcy metabolism in childhood obesity. King Faisal Specialist Hospital and Research Centre 2005 /pmc/articles/PMC6147986/ /pubmed/16119521 http://dx.doi.org/10.5144/0256-4947.2005.209 Text en Copyright © 2005, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Narin, Figen
Atabek, Mehmet Emre
Karakukcu, Musa
Narin, Nazmi
Kurtoglu, Selim
Gumus, Hakan
Çoksevim, Bekir
Erez, Rusen
The association of plasma homocysteine levels with serum leptin and apolipoprotein B levels in childhood obesity
title The association of plasma homocysteine levels with serum leptin and apolipoprotein B levels in childhood obesity
title_full The association of plasma homocysteine levels with serum leptin and apolipoprotein B levels in childhood obesity
title_fullStr The association of plasma homocysteine levels with serum leptin and apolipoprotein B levels in childhood obesity
title_full_unstemmed The association of plasma homocysteine levels with serum leptin and apolipoprotein B levels in childhood obesity
title_short The association of plasma homocysteine levels with serum leptin and apolipoprotein B levels in childhood obesity
title_sort association of plasma homocysteine levels with serum leptin and apolipoprotein b levels in childhood obesity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147986/
https://www.ncbi.nlm.nih.gov/pubmed/16119521
http://dx.doi.org/10.5144/0256-4947.2005.209
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