Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype

X-chromosome inactivation (XCI) is an essential epigenetic process in female mammalian development. Although cell-based studies suggest the potential importance of the Ftx long non-protein-coding RNA (lncRNA) in XCI, its physiological roles in vivo remain unclear. Here we show that targeted deletion...

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Detalles Bibliográficos
Autores principales: Hosoi, Yusuke, Soma, Miki, Shiura, Hirosuke, Sado, Takashi, Hasuwa, Hidetoshi, Abe, Kuniya, Kohda, Takashi, Ishino, Fumitoshi, Kobayashi, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148026/
https://www.ncbi.nlm.nih.gov/pubmed/30237402
http://dx.doi.org/10.1038/s41467-018-06327-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148026/
https://www.ncbi.nlm.nih.gov/pubmed/30237402
http://dx.doi.org/10.1038/s41467-018-06327-6

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