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Anti-inflammatory action of cysteine derivative S-1-propenylcysteine by inducing MyD88 degradation
The degradation of target proteins by small molecules utilizing the cellular proteolytic system is featured as a treatment strategy of several diseases. We found that S-1-propenylcysteine (S1PC) among several cysteine derivatives in aged garlic extract inhibited TLR-mediated IL-6 production by induc...
Autores principales: | Suzuki, Jun-ichiro, Kodera, Yukihiro, Miki, Satomi, Ushijima, Mitsuyasu, Takashima, Miyuki, Matsutomo, Toshiaki, Morihara, Naoaki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148218/ https://www.ncbi.nlm.nih.gov/pubmed/30237533 http://dx.doi.org/10.1038/s41598-018-32431-0 |
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