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Protease-activated receptor 2 signaling modulates susceptibility of colonic epithelium to injury through stabilization of YAP in vivo
Hippo signaling plays critical roles in intestinal regeneration. However, the mechanisms which regulate its activity in vivo are largely unknown. We hypothesize that protease-activated receptor 2 (PAR2) signaling, which could be activated by trypsin, might affect YAP activity in the setting of tissu...
Autores principales: | He, Longmei, Ma, Yiming, Li, Weiwei, Han, Wenxiao, Zhao, Xinhua, Wang, Hongying |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148223/ https://www.ncbi.nlm.nih.gov/pubmed/30237580 http://dx.doi.org/10.1038/s41419-018-0995-x |
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