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C-Abl is not actıvated in DNA damage-induced and Tap63-mediated oocyte apoptosıs in human ovary

There is a controversy in literature as to whether c-Abl is crucial for the induction of TAp63-mediated apoptosis and whether that inhibition of c-Abl with imatinib, which was designed to inhibit the oncogenic kinase BCR-ABL and c-kit, protects oocytes from chemotherapy-induced apoptosis in mice. No...

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Detalles Bibliográficos
Autores principales: Bildik, Gamze, Acılan, Ceyda, Sahin, Gizem Nur, Karahuseyinoglu, Sercin, Oktem, Ozgur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148240/
https://www.ncbi.nlm.nih.gov/pubmed/30237472
http://dx.doi.org/10.1038/s41419-018-1026-7