Overcoming conservation in TALE–DNA interactions: a minimal repeat scaffold enables selective recognition of an oxidized 5-methylcytosine

Transcription-activator-like effectors (TALEs) are repeat-based proteins featuring programmable DNA binding. The repulsion of TALE repeats by 5-methylcytosine (5mC) and its oxidized forms makes TALEs potential probes for their programmable analysis. However, this potential has been limited by the in...

Descripción completa

Detalles Bibliográficos
Autores principales: Maurer, Sara, Buchmuller, Benjamin, Ehrt, Christiane, Jasper, Julia, Koch, Oliver, Summerer, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148557/
https://www.ncbi.nlm.nih.gov/pubmed/30288245
http://dx.doi.org/10.1039/c8sc01958d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148557/
https://www.ncbi.nlm.nih.gov/pubmed/30288245
http://dx.doi.org/10.1039/c8sc01958d

Ejemplares similares