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Molecular and cellular characterizations of human cherubism: disease aggressiveness depends on osteoclast differentiation
BACKGROUND: Cherubism is a rare autosomal dominant disorder of the jaws caused by mutation of the SH3BP2 gene. The bone is replaced by a fibrous granuloma containing multinucleated giant cells. Cells of the cherubism granuloma have never been systematically analyzed. Hence, the aim of this study was...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148781/ https://www.ncbi.nlm.nih.gov/pubmed/30236129 http://dx.doi.org/10.1186/s13023-018-0907-2 |