Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study

Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. Although closely related, these enzymes display very different substrate specificities that only partially overlap. This...

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Detalles Bibliográficos
Autores principales: Rosenberry, Terrone L., Brazzolotto, Xavier, Macdonald, Ian R., Wandhammer, Marielle, Trovaslet-Leroy, Marie, Darvesh, Sultan, Nachon, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149722/
https://www.ncbi.nlm.nih.gov/pubmed/29186056
http://dx.doi.org/10.3390/molecules22122098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149722/
https://www.ncbi.nlm.nih.gov/pubmed/29186056
http://dx.doi.org/10.3390/molecules22122098

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