Spiro[pyrrolidine-3,3′-oxindoles] and Their Indoline Analogues as New 5-HT6 Receptor Chemotypes

Synthetic derivatives of spiro[pyrrolidinyl-3,3′-oxindole] alkaloids (coerulescine analogues) were investigated as new ligands for aminergic G-protein coupled receptors (GPCRs). The chemical starting point 2′-phenylspiro[indoline-3,3′-pyrrolidin]-2-one scaffold was identified by virtual fragment scr...

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Detalles Bibliográficos
Autores principales: Kelemen, Ádám A., Satala, Grzegorz, Bojarski, Andrzej J., Keserű, György M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149751/
https://www.ncbi.nlm.nih.gov/pubmed/29240714
http://dx.doi.org/10.3390/molecules22122221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149751/
https://www.ncbi.nlm.nih.gov/pubmed/29240714
http://dx.doi.org/10.3390/molecules22122221

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