Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP

ARTS (Sept4_i2) is a pro-apoptotic mitochondrial tumor suppressor protein which binds to and causes degradation of XIAP (X-linked inhibitor of apoptosis). We recently showed that ARTS brings XIAP into close proximity to Bcl-2, creating a complex which enables degradation of both these major anti-apo...

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Detalles Bibliográficos
Autores principales: Mamriev, Dana, Larisch, Sarit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149843/
https://www.ncbi.nlm.nih.gov/pubmed/30250908
http://dx.doi.org/10.1080/23723556.2018.1441630
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author Mamriev, Dana
Larisch, Sarit
author_facet Mamriev, Dana
Larisch, Sarit
author_sort Mamriev, Dana
collection PubMed
description ARTS (Sept4_i2) is a pro-apoptotic mitochondrial tumor suppressor protein which binds to and causes degradation of XIAP (X-linked inhibitor of apoptosis). We recently showed that ARTS brings XIAP into close proximity to Bcl-2, creating a complex which enables degradation of both these major anti-apoptotic proteins and promotes apoptosis. The possible therapeutic implications are discussed here.
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spelling pubmed-61498432019-06-25 Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP Mamriev, Dana Larisch, Sarit Mol Cell Oncol Review ARTS (Sept4_i2) is a pro-apoptotic mitochondrial tumor suppressor protein which binds to and causes degradation of XIAP (X-linked inhibitor of apoptosis). We recently showed that ARTS brings XIAP into close proximity to Bcl-2, creating a complex which enables degradation of both these major anti-apoptotic proteins and promotes apoptosis. The possible therapeutic implications are discussed here. Taylor & Francis 2018-06-25 /pmc/articles/PMC6149843/ /pubmed/30250908 http://dx.doi.org/10.1080/23723556.2018.1441630 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Mamriev, Dana
Larisch, Sarit
Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP
title Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP
title_full Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP
title_fullStr Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP
title_full_unstemmed Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP
title_short Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP
title_sort another one bites the dust; arts enables degradation of bcl-2 by xiap
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149843/
https://www.ncbi.nlm.nih.gov/pubmed/30250908
http://dx.doi.org/10.1080/23723556.2018.1441630
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