Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors

Inhibitors of human lactate dehydrogenase (hLDH5)—the enzyme responsible for the conversion of pyruvate to lactate coupled with oxidation of NADH to NAD(+)—are promising therapeutic agents against cancer because this enzyme is generally found to be overexpressed in most invasive cancer cells and is...

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Detalles Bibliográficos
Autores principales: Poli, Giulio, Granchi, Carlotta, Aissaoui, Mohamed, Minutolo, Filippo, Tuccinardi, Tiziano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149858/
https://www.ncbi.nlm.nih.gov/pubmed/29236080
http://dx.doi.org/10.3390/molecules22122217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149858/
https://www.ncbi.nlm.nih.gov/pubmed/29236080
http://dx.doi.org/10.3390/molecules22122217

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