Killing two birds with one stone: Blocking the mitochondrial pyruvate carrier to inhibit lactate uptake by cancer cells and radiosensitize tumors

Lactate-based metabolic symbiosis between glycolytic and oxidative cancer cells is known to facilitate tumor growth. We have recently demonstrated that 7ACC2 blocks extracellular lactate uptake via the inhibition of mitochondrial pyruvate carrier. 7ACC2 also prevents compensatory glucose oxidation,...

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Detalles Bibliográficos
Autores principales: Linden, Catherine Vander, Corbet, Cyril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149896/
https://www.ncbi.nlm.nih.gov/pubmed/30250917
http://dx.doi.org/10.1080/23723556.2018.1465016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149896/
https://www.ncbi.nlm.nih.gov/pubmed/30250917
http://dx.doi.org/10.1080/23723556.2018.1465016

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