Asparagine, a critical limiting metabolite during glutamine starvation

A challenge of targeting glutamine metabolism in cancer is that tumor cells develop various strategies to adapt to glutamine limitation. We found that asparagine plays a critical role in supporting protein synthesis during glutamine starvation, highlighting a possible approach to optimize the therap...

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Detalles Bibliográficos
Autores principales: Jiang, Jie, Pavlova, Natalya N, Zhang, Ji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149945/
https://www.ncbi.nlm.nih.gov/pubmed/30250896
http://dx.doi.org/10.1080/23723556.2018.1441633
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author Jiang, Jie
Pavlova, Natalya N
Zhang, Ji
author_facet Jiang, Jie
Pavlova, Natalya N
Zhang, Ji
author_sort Jiang, Jie
collection PubMed
description A challenge of targeting glutamine metabolism in cancer is that tumor cells develop various strategies to adapt to glutamine limitation. We found that asparagine plays a critical role in supporting protein synthesis during glutamine starvation, highlighting a possible approach to optimize the therapeutic efficacy of targeting glutamine metabolism in cancer.
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spelling pubmed-61499452019-04-11 Asparagine, a critical limiting metabolite during glutamine starvation Jiang, Jie Pavlova, Natalya N Zhang, Ji Mol Cell Oncol Author's Views A challenge of targeting glutamine metabolism in cancer is that tumor cells develop various strategies to adapt to glutamine limitation. We found that asparagine plays a critical role in supporting protein synthesis during glutamine starvation, highlighting a possible approach to optimize the therapeutic efficacy of targeting glutamine metabolism in cancer. Taylor & Francis 2018-04-11 /pmc/articles/PMC6149945/ /pubmed/30250896 http://dx.doi.org/10.1080/23723556.2018.1441633 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Jiang, Jie
Pavlova, Natalya N
Zhang, Ji
Asparagine, a critical limiting metabolite during glutamine starvation
title Asparagine, a critical limiting metabolite during glutamine starvation
title_full Asparagine, a critical limiting metabolite during glutamine starvation
title_fullStr Asparagine, a critical limiting metabolite during glutamine starvation
title_full_unstemmed Asparagine, a critical limiting metabolite during glutamine starvation
title_short Asparagine, a critical limiting metabolite during glutamine starvation
title_sort asparagine, a critical limiting metabolite during glutamine starvation
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149945/
https://www.ncbi.nlm.nih.gov/pubmed/30250896
http://dx.doi.org/10.1080/23723556.2018.1441633
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AT pavlovanatalyan asparagineacriticallimitingmetaboliteduringglutaminestarvation
AT zhangji asparagineacriticallimitingmetaboliteduringglutaminestarvation

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