Regulation of G2/M Transition by Inhibition of WEE1 and PKMYT1 Kinases

In the cell cycle, there are two checkpoint arrests that allow cells to repair damaged DNA in order to maintain genomic integrity. Many cancer cells have defective G1 checkpoint mechanisms, thus depending on the G2 checkpoint far more than normal cells. G2 checkpoint abrogation is therefore a promis...

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Detalles Bibliográficos
Autores principales: Schmidt, Matthias, Rohe, Alexander, Platzer, Charlott, Najjar, Abdulkarim, Erdmann, Frank, Sippl, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149964/
https://www.ncbi.nlm.nih.gov/pubmed/29168755
http://dx.doi.org/10.3390/molecules22122045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149964/
https://www.ncbi.nlm.nih.gov/pubmed/29168755
http://dx.doi.org/10.3390/molecules22122045

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