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Temozolomide resistance in glioblastoma multiforme
Temozolomide (TMZ) is an oral alkylating agent used to treat glioblastoma multiforme (GBM) and astrocytomas. However, at least 50% of TMZ treated patients do not respond to TMZ. This is due primarily to the over-expression of O(6)-methylguanine methyltransferase (MGMT) and/or lack of a DNA repair pa...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Chongqing Medical University
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150109/ https://www.ncbi.nlm.nih.gov/pubmed/30258889 http://dx.doi.org/10.1016/j.gendis.2016.04.007 |