Novel α, β-Unsaturated Sophoridinic Derivatives: Design, Synthesis, Molecular Docking and Anti-Cancer Activities

Using sophoridine 1 and chalcone 3 as the lead compounds, a series of novel α, β-unsaturated sophoridinic derivatives were designed, synthesized, and evaluated for their in vitro cytotoxicity. Structure-activity relationship (SAR) analysis indicated that introduction of α, β-unsaturated ketone moiet...

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Detalles Bibliográficos
Autores principales: Xu, Yiming, Wu, Lichuan, Dai, Hang, Gao, Mingyan, Ur Rashid, Haroon, Wang, Haodong, Xie, Peng, Liu, Xu, Jiang, Jun, Wang, Lisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150263/
https://www.ncbi.nlm.nih.gov/pubmed/29135958
http://dx.doi.org/10.3390/molecules22111967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150263/
https://www.ncbi.nlm.nih.gov/pubmed/29135958
http://dx.doi.org/10.3390/molecules22111967

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