‘Click Chemistry’ Synthesis of Novel Natural Product-Like Caged Xanthones Bearing a 1,2,3-Triazole Moiety with Improved Druglike Properties as Orally Active Antitumor Agents

DDO-6101, a natural-product-like caged xanthone discovered previously in our laboratory based on the pharmacophoric scaffold of the Garcinia natural product gambogic acid (GA), shows potent cytotoxicity in vitro, but poor efficacy in vivo due to its poor druglike properties. In order to improve the...

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Detalles Bibliográficos
Autores principales: Li, Xiang, Wu, Yue, Wang, Yanyan, You, Qidong, Zhang, Xiaojin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150271/
https://www.ncbi.nlm.nih.gov/pubmed/29077076
http://dx.doi.org/10.3390/molecules22111834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150271/
https://www.ncbi.nlm.nih.gov/pubmed/29077076
http://dx.doi.org/10.3390/molecules22111834

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