Synthesis and Molecular Modeling Studies of N′-Hydroxyindazolecarboximidamides as Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunosuppressive enzyme that is highly overexpressed in various cancer cells and antigen-presenting cells. It has emerged as an attractive therapeutic target for cancer immunotherapy, which has prompted high interest in the development of small-molecule in...

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Detalles Bibliográficos
Autores principales: Lee, Dong-Ho, Lee, Joo-Youn, Jeong, Jieun, Kim, Miok, Lee, Kyung Won, Jang, Eunseo, Ahn, Sunjoo, Lee, Chang Hoon, Hwang, Jong Yeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150275/
https://www.ncbi.nlm.nih.gov/pubmed/29120388
http://dx.doi.org/10.3390/molecules22111936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150275/
https://www.ncbi.nlm.nih.gov/pubmed/29120388
http://dx.doi.org/10.3390/molecules22111936

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