A Search for Dual Action HIV-1 Reverse Transcriptase, Bacterial RNA Polymerase Inhibitors

Using molecular modeling approach, potential antibacterial agents with triazole core were proposed. A moderate to weak level of antibacterial activity in most of the compounds have been observed, with best minimal inhibitory concentration (MIC) value of 0.003 mg/mL, as shown by the 15 against S. epi...

Descripción completa

Detalles Bibliográficos
Autores principales: Paneth, Agata, Frączek, Tomasz, Grzegorczyk, Agnieszka, Janowska, Dominika, Malm, Anna, Paneth, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150362/
https://www.ncbi.nlm.nih.gov/pubmed/29068373
http://dx.doi.org/10.3390/molecules22111808
_version_ 1783356976772677632
author Paneth, Agata
Frączek, Tomasz
Grzegorczyk, Agnieszka
Janowska, Dominika
Malm, Anna
Paneth, Piotr
author_facet Paneth, Agata
Frączek, Tomasz
Grzegorczyk, Agnieszka
Janowska, Dominika
Malm, Anna
Paneth, Piotr
author_sort Paneth, Agata
collection PubMed
description Using molecular modeling approach, potential antibacterial agents with triazole core were proposed. A moderate to weak level of antibacterial activity in most of the compounds have been observed, with best minimal inhibitory concentration (MIC) value of 0.003 mg/mL, as shown by the 15 against S. epidermidis. Studied compounds were also submitted to the antifungal assay. The best antifungal activity was detected for 16 with MIC at 0.125 and 0.25 mg/mL against C. albicans and C. parapsilosis, respectively.
format Online
Article
Text
id pubmed-6150362
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-61503622018-11-13 A Search for Dual Action HIV-1 Reverse Transcriptase, Bacterial RNA Polymerase Inhibitors Paneth, Agata Frączek, Tomasz Grzegorczyk, Agnieszka Janowska, Dominika Malm, Anna Paneth, Piotr Molecules Article Using molecular modeling approach, potential antibacterial agents with triazole core were proposed. A moderate to weak level of antibacterial activity in most of the compounds have been observed, with best minimal inhibitory concentration (MIC) value of 0.003 mg/mL, as shown by the 15 against S. epidermidis. Studied compounds were also submitted to the antifungal assay. The best antifungal activity was detected for 16 with MIC at 0.125 and 0.25 mg/mL against C. albicans and C. parapsilosis, respectively. MDPI 2017-10-25 /pmc/articles/PMC6150362/ /pubmed/29068373 http://dx.doi.org/10.3390/molecules22111808 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Paneth, Agata
Frączek, Tomasz
Grzegorczyk, Agnieszka
Janowska, Dominika
Malm, Anna
Paneth, Piotr
A Search for Dual Action HIV-1 Reverse Transcriptase, Bacterial RNA Polymerase Inhibitors
title A Search for Dual Action HIV-1 Reverse Transcriptase, Bacterial RNA Polymerase Inhibitors
title_full A Search for Dual Action HIV-1 Reverse Transcriptase, Bacterial RNA Polymerase Inhibitors
title_fullStr A Search for Dual Action HIV-1 Reverse Transcriptase, Bacterial RNA Polymerase Inhibitors
title_full_unstemmed A Search for Dual Action HIV-1 Reverse Transcriptase, Bacterial RNA Polymerase Inhibitors
title_short A Search for Dual Action HIV-1 Reverse Transcriptase, Bacterial RNA Polymerase Inhibitors
title_sort search for dual action hiv-1 reverse transcriptase, bacterial rna polymerase inhibitors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150362/
https://www.ncbi.nlm.nih.gov/pubmed/29068373
http://dx.doi.org/10.3390/molecules22111808
work_keys_str_mv AT panethagata asearchfordualactionhiv1reversetranscriptasebacterialrnapolymeraseinhibitors
AT fraczektomasz asearchfordualactionhiv1reversetranscriptasebacterialrnapolymeraseinhibitors
AT grzegorczykagnieszka asearchfordualactionhiv1reversetranscriptasebacterialrnapolymeraseinhibitors
AT janowskadominika asearchfordualactionhiv1reversetranscriptasebacterialrnapolymeraseinhibitors
AT malmanna asearchfordualactionhiv1reversetranscriptasebacterialrnapolymeraseinhibitors
AT panethpiotr asearchfordualactionhiv1reversetranscriptasebacterialrnapolymeraseinhibitors
AT panethagata searchfordualactionhiv1reversetranscriptasebacterialrnapolymeraseinhibitors
AT fraczektomasz searchfordualactionhiv1reversetranscriptasebacterialrnapolymeraseinhibitors
AT grzegorczykagnieszka searchfordualactionhiv1reversetranscriptasebacterialrnapolymeraseinhibitors
AT janowskadominika searchfordualactionhiv1reversetranscriptasebacterialrnapolymeraseinhibitors
AT malmanna searchfordualactionhiv1reversetranscriptasebacterialrnapolymeraseinhibitors
AT panethpiotr searchfordualactionhiv1reversetranscriptasebacterialrnapolymeraseinhibitors

Ejemplares similares