Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors

A novel series of 2-substituted-4,6-diarylpyrimidines 6a–6t has been synthesized, characterized by (1)H-NMR, (13)C-NMR and HRMS, and screened for in vitro α-glucosidase inhibitory activity. The majority of the screened compounds possessed significant α-glucosidase inhibitory activity with IC(50) val...

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Detalles Bibliográficos
Autores principales: Gong, Zipeng, Xie, Zhenzhen, Qiu, Jie, Wang, Guangcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150375/
https://www.ncbi.nlm.nih.gov/pubmed/29084182
http://dx.doi.org/10.3390/molecules22111865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150375/
https://www.ncbi.nlm.nih.gov/pubmed/29084182
http://dx.doi.org/10.3390/molecules22111865

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