Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors

A novel series of 2-substituted-4,6-diarylpyrimidines 6a–6t has been synthesized, characterized by (1)H-NMR, (13)C-NMR and HRMS, and screened for in vitro α-glucosidase inhibitory activity. The majority of the screened compounds possessed significant α-glucosidase inhibitory activity with IC(50) val...

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Detalles Bibliográficos
Autores principales: Gong, Zipeng, Xie, Zhenzhen, Qiu, Jie, Wang, Guangcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150375/
https://www.ncbi.nlm.nih.gov/pubmed/29084182
http://dx.doi.org/10.3390/molecules22111865
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author Gong, Zipeng
Xie, Zhenzhen
Qiu, Jie
Wang, Guangcheng
author_facet Gong, Zipeng
Xie, Zhenzhen
Qiu, Jie
Wang, Guangcheng
author_sort Gong, Zipeng
collection PubMed
description A novel series of 2-substituted-4,6-diarylpyrimidines 6a–6t has been synthesized, characterized by (1)H-NMR, (13)C-NMR and HRMS, and screened for in vitro α-glucosidase inhibitory activity. The majority of the screened compounds possessed significant α-glucosidase inhibitory activity with IC(50) values ranging from 19.6 ± 0.21 to 38.9 ± 0.35 μM, which is more potent than the positive control α-glucosidase inhibitor acarbose (IC(50) = 817.38 ± 6.27 μM). Among them, 6j was found to be the most active compound against α-glucosidase with an IC(50) of 19.6 ± 0.21 μM. In addition, molecular docking studies were carried out to explore the binding interactions of 2-substituted-4,6-diarylpyrimidine derivatives with α-glucosidase.
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spelling pubmed-61503752018-11-13 Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors Gong, Zipeng Xie, Zhenzhen Qiu, Jie Wang, Guangcheng Molecules Article A novel series of 2-substituted-4,6-diarylpyrimidines 6a–6t has been synthesized, characterized by (1)H-NMR, (13)C-NMR and HRMS, and screened for in vitro α-glucosidase inhibitory activity. The majority of the screened compounds possessed significant α-glucosidase inhibitory activity with IC(50) values ranging from 19.6 ± 0.21 to 38.9 ± 0.35 μM, which is more potent than the positive control α-glucosidase inhibitor acarbose (IC(50) = 817.38 ± 6.27 μM). Among them, 6j was found to be the most active compound against α-glucosidase with an IC(50) of 19.6 ± 0.21 μM. In addition, molecular docking studies were carried out to explore the binding interactions of 2-substituted-4,6-diarylpyrimidine derivatives with α-glucosidase. MDPI 2017-10-30 /pmc/articles/PMC6150375/ /pubmed/29084182 http://dx.doi.org/10.3390/molecules22111865 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gong, Zipeng
Xie, Zhenzhen
Qiu, Jie
Wang, Guangcheng
Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors
title Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors
title_full Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors
title_fullStr Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors
title_full_unstemmed Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors
title_short Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors
title_sort synthesis, biological evaluation and molecular docking study of 2-substituted-4,6-diarylpyrimidines as α-glucosidase inhibitors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150375/
https://www.ncbi.nlm.nih.gov/pubmed/29084182
http://dx.doi.org/10.3390/molecules22111865
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