Cargando…

Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors

A novel series of 2-substituted-4,6-diarylpyrimidines 6a–6t has been synthesized, characterized by (1)H-NMR, (13)C-NMR and HRMS, and screened for in vitro α-glucosidase inhibitory activity. The majority of the screened compounds possessed significant α-glucosidase inhibitory activity with IC(50) val...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gong, Zipeng, Xie, Zhenzhen, Qiu, Jie, Wang, Guangcheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150375/ https://www.ncbi.nlm.nih.gov/pubmed/29084182 http://dx.doi.org/10.3390/molecules22111865

Ejemplares similares

ZnO Catalyzed Efficient Synthesis of Some New 2-Substituted-4,6-diarylpyrimidines
por: Ameta, K. L., et al.
Publicado: (2012)

Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Isatin-Thiazole Derivatives as α-Glucosidase Inhibitors
por: Xie, Zhenzhen, et al.
Publicado: (2017)

Synthesis, In Vitro α-Glucosidase Inhibitory Activity and Molecular Docking Studies of Novel Benzothiazole-Triazole Derivatives
por: Gong, Zipeng, et al.
Publicado: (2017)

Synthesis and Molecular Docking Studies of Alkoxy- and Imidazole-Substituted Xanthones as α-Amylase and α-Glucosidase Inhibitors
por: Aguila-Muñoz, Dolores G., et al.
Publicado: (2023)

Synthesis, biological activity and molecular docking of new tricyclic series as α-glucosidase inhibitors
por: Abuelizz, Hatem A., et al.
Publicado: (2019)

Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A(1) Antagonists
por: Val, Cristina, et al.
Publicado: (2022)

Synthesis of novel coumarin–hydrazone hybrids as α-glucosidase inhibitors and their molecular docking studies
por: Tariq, Hafiza Zara, et al.
Publicado: (2023)

Design, synthesis, and molecular docking studies of diphenylquinoxaline-6-carbohydrazide hybrids as potent α-glucosidase inhibitors
por: Pedrood, Keyvan, et al.
Publicado: (2022)

Application of 3D-QSAR, Pharmacophore, and Molecular Docking in the Molecular Design of Diarylpyrimidine Derivatives as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors
por: Liu, Genyan, et al.
Publicado: (2018)

Synthesis, in vitro biological assessment, and molecular docking study of benzimidazole-based thiadiazole derivatives as dual inhibitors of α-amylase and α-glucosidase
por: Khan, Shoaib, et al.
Publicado: (2023)

Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising α-Glucosidase Inhibitors
por: Wang, Haibo, et al.
Publicado: (2022)

Synthesis of Novel N-Methylmorpholine-Substituted Benzimidazolium Salts as Potential α-Glucosidase Inhibitors
por: Khan, Imran Ahmad, et al.
Publicado: (2022)

Development of fluorine-substituted NH(2)-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors: Boosting the safety and metabolic stability
por: Jin, Xin, et al.
Publicado: (2023)

Synthesis of Novel Triazinoindole-Based Thiourea Hybrid: A Study on α-Glucosidase Inhibitors and Their Molecular Docking
por: Taha, Muhammad, et al.
Publicado: (2019)

Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors
por: Jiang, Xiangyi, et al.
Publicado: (2023)

Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy
por: Lei, Yuan, et al.
Publicado: (2020)

Novel oxadiazole derivatives as potent inhibitors of α-amylase and α-glucosidase enzymes: Synthesis, in vitro evaluation, and molecular docking studies
por: Bukhari, Asma, et al.
Publicado: (2021)

Identification of Boronate-Containing Diarylpyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors
por: Feng, Da, et al.
Publicado: (2022)

Synthesis and biological evaluation of novel ursolic acid analogues as potential α-glucosidase inhibitors
por: Wu, Pan-Pan, et al.
Publicado: (2017)

Novel C-2 Symmetric Molecules as α-Glucosidase and α-Amylase Inhibitors: Design, Synthesis, Kinetic Evaluation, Molecular Docking and Pharmacokinetics
por: Shahzad, Danish, et al.
Publicado: (2019)

Benzimidazole Bearing Thiosemicarbazone Derivatives Act as Potent α-Amylase and α-Glucosidase Inhibitors; Synthesis, Bioactivity Screening and Molecular Docking Study
por: Ullah, Hayat, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of 5-Fluoro-2-Oxindole Derivatives as Potential α-Glucosidase Inhibitors
por: Lin, Jing, et al.
Publicado: (2022)

Synthesis of Novel Benzimidazole-Based Thiazole Derivatives as Multipotent Inhibitors of α-Amylase and α-Glucosidase: In Vitro Evaluation along with Molecular Docking Study
por: Hussain, Rafaqat, et al.
Publicado: (2022)

Synthesis of amantadine clubbed N-aryl amino thiazoles as potent urease, α-amylase & α-glucosidase inhibitors, kinetic and molecular docking studies
por: Zahra, Fatima Tuz, et al.
Publicado: (2023)

Synthesis and Evaluation of Coumarin-Chalcone Derivatives as α-Glucosidase Inhibitors
por: Hu, Chun-Mei, et al.
Publicado: (2022)

Triazoloquinazolines as a new class of potent α-glucosidase inhibitors: in vitro evaluation and docking study
por: Abuelizz, Hatem A., et al.
Publicado: (2019)

Molecular Docking of Isolated Alkaloids for Possible α-Glucosidase Inhibition
por: Rahman, Noor, et al.
Publicado: (2019)

In vitro and molecular docking analysis of chalconeimine derivatives with α-glucosidase
por: Asaithambi, R, et al.
Publicado: (2020)

Identification of Novel Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors by Exploring the Primer Grip Region
por: Zhang, Tao, et al.
Publicado: (2022)

Synthesis, in vitro inhibitory activity, kinetic study and molecular docking of novel N-alkyl–deoxynojirimycin derivatives as potential α-glucosidase inhibitors
por: Lin, Ping, et al.
Publicado: (2020)

Design and Synthesis of New Benzimidazole and Pyrimidine Derivatives as α-glucosidase Inhibitor
por: Mobinikhaledi, Akbar, et al.
Publicado: (2015)

In-vitro high-throughput library screening—Kinetics and molecular docking studies of potent inhibitors of α-glucosidase
por: Ali, Majid, et al.
Publicado: (2023)

Synthesis of Benzylidene Analogs of Oleanolic Acid as Potential α-Glucosidase and α-Amylase Inhibitors
por: Ke, Jun-Jie, et al.
Publicado: (2022)

Synthesis, Molecular Docking, and Bioactivity Study of Novel Hybrid Benzimidazole Urea Derivatives: A Promising α-Amylase and α-Glucosidase Inhibitor Candidate with Antioxidant Activity
por: Aroua, Lotfi M., et al.
Publicado: (2023)

Hypoglycemic Efficacy of Docking Selected Natural Compounds against α-Glucosidase and α-Amylase
por: Riyaphan, Jirawat, et al.
Publicado: (2018)

Design, synthesis, biological evaluation, and molecular modeling studies of pyrazole-benzofuran hybrids as new α-glucosidase inhibitor
por: Azimi, Fateme, et al.
Publicado: (2021)

Discovery of New α-Glucosidase Inhibitors: Structure-Based Virtual Screening and Biological Evaluation
por: Liu, Shan-Kui, et al.
Publicado: (2021)

Pyridine substituted BODIPYs: synthesis, characterization and cholinesterease, α-glucosidase inhibitory, DNA hydrolytic cleavage effects
por: BARUT, Burak, et al.
Publicado: (2021)

Correction: In-vitro high-throughput library screening—Kinetics and molecular docking studies of potent inhibitors of α-glucosidase
Publicado: (2023)

Designing Potent α-Glucosidase Inhibitors: A Synthesis and QSAR Modeling Approach for Biscoumarin Derivatives
por: Phan, Thi-Hong-Truc, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qi1pvnjmdlnv83i2iitjv037r7