Influence of Amlodipine Enantiomers on Human Microsomal Cytochromes P450: Stereoselective Time-Dependent Inhibition of CYP3A Enzyme Activity

Amlodipine (AML) is available as a racemate, i.e., a mixture of R- and S-enantiomers. Its inhibitory potency towards nine cytochromes P450 (CYP) was studied to evaluate the drug–drug interactions between the enantiomers. Enzyme inhibition was evaluated using specific CYP substrates in human liver mi...

Descripción completa

Detalles Bibliográficos
Autores principales: Krasulova, Kristyna, Holas, Ondrej, Anzenbacher, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150391/
https://www.ncbi.nlm.nih.gov/pubmed/29099769
http://dx.doi.org/10.3390/molecules22111879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150391/
https://www.ncbi.nlm.nih.gov/pubmed/29099769
http://dx.doi.org/10.3390/molecules22111879

Ejemplares similares