Cargando…

Influence of Amlodipine Enantiomers on Human Microsomal Cytochromes P450: Stereoselective Time-Dependent Inhibition of CYP3A Enzyme Activity

Amlodipine (AML) is available as a racemate, i.e., a mixture of R- and S-enantiomers. Its inhibitory potency towards nine cytochromes P450 (CYP) was studied to evaluate the drug–drug interactions between the enantiomers. Enzyme inhibition was evaluated using specific CYP substrates in human liver mi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krasulova, Kristyna, Holas, Ondrej, Anzenbacher, Pavel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150391/ https://www.ncbi.nlm.nih.gov/pubmed/29099769 http://dx.doi.org/10.3390/molecules22111879

Ejemplares similares

Dual Effects of Ketoconazole cis-Enantiomers on CYP3A4 in Human Hepatocytes and HepG2 Cells
por: Novotná, Aneta, et al.
Publicado: (2014)

Nerolidol and Farnesol Inhibit Some Cytochrome P450 Activities but Did Not Affect Other Xenobiotic-Metabolizing Enzymes in Rat and Human Hepatic Subcellular Fractions
por: Špičáková, Alena, et al.
Publicado: (2017)

Inhibition of cytochrome P450 enzymes by thymoquinone in human liver microsomes
por: Albassam, Ahmed A., et al.
Publicado: (2018)

Inhibitory mechanism of vortioxetine on CYP450 enzymes in human and rat liver microsomes
por: Zhan, Yunyun, et al.
Publicado: (2023)

Effects of Eupatilin and Jaceosidin on Cytochrome P450 Enzyme Activities in Human Liver Microsomes
por: Ji, Hye Young, et al.
Publicado: (2010)

Succinic acid inhibits the activity of cytochrome P450 (CYP450) enzymes
por: Wang, Hao, et al.
Publicado: (2020)

Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP-glucuronosyltransferases
por: Illingworth, NA, et al.
Publicado: (2011)

Effect of Honokiol on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes
por: Jeong, Hyeon-Uk, et al.
Publicado: (2013)

Characterization of furathiocarb metabolism in in-vitro human liver microsomes and recombinant cytochrome P450 enzymes
por: Abass, Khaled, et al.
Publicado: (2022)

Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs
por: Soucek, Pavel, et al.
Publicado: (2001)

Inhibition of Cytochrome P450 by Propolis in Human Liver Microsomes
por: Ryu, Chang Seon, et al.
Publicado: (2016)

Exploring the Potential of Cytochrome P450 CYP109B1 Catalyzed Regio—and Stereoselective Steroid Hydroxylation
por: Zhang, Xiaodong, et al.
Publicado: (2021)

Polymorphic Cytochrome P450 Enzymes (CYPs) and Their Role in Personalized Therapy
por: Preissner, Sarah C., et al.
Publicado: (2013)

Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes
por: Raunio, Hannu, et al.
Publicado: (2015)

Corydaline Inhibits Multiple Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes
por: Ji, Hye Young, et al.
Publicado: (2011)

Computational redesign of cytochrome P450 CYP102A1 for highly stereoselective omeprazole hydroxylation by UniDesign
por: Huang, Xiaoqiang, et al.
Publicado: (2023)

Cytochrome P450 metabolism studies of [6]-gingerol, [8]-gingerol, and [10]-gingerol by liver microsomes of humans and different species combined with expressed CYP enzymes
por: Chen, Chanjuan, et al.
Publicado: (2023)

Enantioselectivity in the cytochrome P450-dependent conversion of tegafur to 5-fluorouracil in human liver microsomes
por: Yamamiya, Ikuo, et al.
Publicado: (2013)

Gut Microbiome Alters the Activity of Liver Cytochromes P450 in Mice With Sex-Dependent Differences
por: Jourová, Lenka, et al.
Publicado: (2020)

Effects of Flavonoids in Lysimachia clethroides Duby on the Activities of Cytochrome P450 CYP2E1 and CYP3A4 in Rat Liver Microsomes
por: Zhang, Zhi-Juan, et al.
Publicado: (2016)

Influence of Selected Carbon Nanostructures on the CYP2C9 Enzyme of the P450 Cytochrome
por: Sekretarska, Justyna, et al.
Publicado: (2019)

The cytochrome P450 (CYP) superfamily in cnidarians
por: Pankov, Kirill V., et al.
Publicado: (2021)

Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes
por: Lu, Yan, et al.
Publicado: (2017)

Inhibitory Effects of Aschantin on Cytochrome P450 and Uridine 5′-diphospho-glucuronosyltransferase Enzyme Activities in Human Liver Microsomes
por: Kwon, Soon-Sang, et al.
Publicado: (2016)

Nonalcoholic Fatty Liver Disease (NAFLD) and Hepatic Cytochrome P450 (CYP) Enzymes
por: Jamwal, Rohitash, et al.
Publicado: (2020)

Effects of cytochrome P450 oxidoreductase genotypes on the pharmacokinetics of amlodipine in healthy Korean subjects
por: Han, Ji Min, et al.
Publicado: (2020)

Functioning of Microsomal Cytochrome P450s: Murburn Concept Explains the Metabolism of Xenobiotics in Hepatocytes
por: Manoj, Kelath Murali, et al.
Publicado: (2016)

Interaction Modes of Microsomal Cytochrome P450s with Its Reductase and the Role of Substrate Binding
por: Esteves, Francisco, et al.
Publicado: (2020)

Validation of an HPLC Method for the Simultaneous Quantification of Metabolic Reaction Products Catalysed by CYP2E1 Enzyme Activity: Inhibitory Effect of Cytochrome P450 Enzyme CYP2E1 by Salicylic Acid in Rat Liver Microsomes
por: Salhab, Hassan, et al.
Publicado: (2020)

Stereoselective Toxicokinetic and Distribution Study on the Hexaconazole Enantiomers in Mice
por: Luo, Guofei, et al.
Publicado: (2023)

Membrane Position of Ibuprofen Agrees with Suggested Access Path Entrance to Cytochrome P450 2C9 Active Site
por: Berka, Karel, et al.
Publicado: (2011)

AM-2201 Inhibits Multiple Cytochrome P450 and Uridine 5′-Diphospho-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes
por: Kim, Ju-Hyun, et al.
Publicado: (2017)

Inhibitory Effects of Dimethyllirioresinol, Epimagnolin A, Eudesmin, Fargesin, and Magnolin on Cytochrome P450 Enzyme Activities in Human Liver Microsomes
por: Kim, Ju-Hyun, et al.
Publicado: (2017)

Liver microsomal lipid enhances the activity and redox coupling of colocalized cytochrome P450 reductase‐cytochrome P450 3A4 in nanodiscs
por: Liu, Kang‐Cheng, et al.
Publicado: (2017)

Regio‐ and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants
por: Li, Aitao, et al.
Publicado: (2020)

Microsomal cytochrome P-450-linked monooxygenase systems and lipid composition of human hepatocellular carcinoma.
por: Hamamoto, I., et al.
Publicado: (1989)

Immunoelectron microscope localization of cytochrome P-450 on microsomes and other membrane structures of rat hepatocytes
Publicado: (1978)

Effects of Eleutheroside B and Eleutheroside E on activity of cytochrome P450 in rat liver microsomes
por: Guo, Sixun, et al.
Publicado: (2014)

Characterization of the metabolism of eupalinolide A and B by carboxylesterase and cytochrome P450 in human liver microsomes
por: Li, Yingzi, et al.
Publicado: (2023)

Highly Cytotoxic Copper(II) Mixed-Ligand Quinolinonato Complexes: Pharmacokinetic Properties and Interactions with Drug Metabolizing Cytochromes P450
por: Medvedíková, Martina, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_32nga463vch3shdgmdn0s2ik62