Adding an Artificial Tail—Anchor to a Peptide-Based HIV-1 Fusion Inhibitor for Improvement of Its Potency and Resistance Profile

Peptides derived from the C-terminal heptad repeat (CHR) of human immunodeficiency virus type 1 (HIV-1) envelope protein transmembrane subunit gp41, such as T20 (enfuvirtide), can bind to the N-terminal heptad repeat (NHR) of gp41 and block six-helix bundle (6-HB) formation, thus inhibiting HIV-1 fu...

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Detalles Bibliográficos
Autores principales: Su, Shan, Ma, Zhenxuan, Hua, Chen, Li, Weihua, Lu, Lu, Jiang, Shibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150406/
https://www.ncbi.nlm.nih.gov/pubmed/29156603
http://dx.doi.org/10.3390/molecules22111996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150406/
https://www.ncbi.nlm.nih.gov/pubmed/29156603
http://dx.doi.org/10.3390/molecules22111996

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