The low spike density of HIV may have evolved because of the effects of T helper cell depletion on affinity maturation

The spikes on virus surfaces bind receptors on host cells to propagate infection. High spike densities (SDs) can promote infection, but spikes are also targets of antibody-mediated immune responses. Thus, diverse evolutionary pressures can influence virus SDs. HIV’s SD is about two orders of magnitu...

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Detalles Bibliográficos
Autores principales: Amitai, Assaf, Chakraborty, Arup K., Kardar, Mehran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150518/
https://www.ncbi.nlm.nih.gov/pubmed/30161121
http://dx.doi.org/10.1371/journal.pcbi.1006408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150518/
https://www.ncbi.nlm.nih.gov/pubmed/30161121
http://dx.doi.org/10.1371/journal.pcbi.1006408

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