Gi/o-coupled muscarinic receptors co-localize with GIRK channel for efficient channel activation

G protein-gated inwardly rectifying K(+) (GIRK) channel regulates cellular excitability upon activation of Gi/o-coupled receptors. In Gi/o-coupled muscarinic M(2)R, the intracellular third loop (i3) is known as a key domain for Gi/o coupling, because replacement of i3 of Gq-coupled muscarinic M(1)R...

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Detalles Bibliográficos
Autores principales: Tateyama, Michihiro, Kubo, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150519/
https://www.ncbi.nlm.nih.gov/pubmed/30240440
http://dx.doi.org/10.1371/journal.pone.0204447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150519/
https://www.ncbi.nlm.nih.gov/pubmed/30240440
http://dx.doi.org/10.1371/journal.pone.0204447

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