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Gi/o-coupled muscarinic receptors co-localize with GIRK channel for efficient channel activation
G protein-gated inwardly rectifying K(+) (GIRK) channel regulates cellular excitability upon activation of Gi/o-coupled receptors. In Gi/o-coupled muscarinic M(2)R, the intracellular third loop (i3) is known as a key domain for Gi/o coupling, because replacement of i3 of Gq-coupled muscarinic M(1)R...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150519/ https://www.ncbi.nlm.nih.gov/pubmed/30240440 http://dx.doi.org/10.1371/journal.pone.0204447 |