Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P(2) but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation

PIKfyve, an evolutionarily conserved kinase synthesizing PtdIns5P and PtdIns(3,5)P(2), is crucial for mammalian cell proliferation and viability. Accordingly, PIKfyve inhibitors are now in clinical trials as anti-cancer drugs. Among those, apilimod is the most promising, yet its potency to inhibit P...

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Detalles Bibliográficos
Autores principales: Sbrissa, Diego, Naisan, Ghassan, Ikonomov, Ognian C., Shisheva, Assia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150535/
https://www.ncbi.nlm.nih.gov/pubmed/30240452
http://dx.doi.org/10.1371/journal.pone.0204532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150535/
https://www.ncbi.nlm.nih.gov/pubmed/30240452
http://dx.doi.org/10.1371/journal.pone.0204532

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