Enhanced Specific Activity by Multichelation of Exendin-3 Leads To Improved Image Quality and In Vivo Beta Cell Imaging

[Image: see text] Glucagon-like peptide-1 receptor (GLP-1R) targeting using radiolabeled exendin is a promising approach to noninvasively visualize and determine beta cell mass (BCM), which could help to unravel the pathophysiology of diabetes. However, saturation of the GLP-1R on beta cells occurs...

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Detalles Bibliográficos
Autores principales: Joosten, Lieke, Brom, Maarten, Peeters, Hanneke, Heskamp, Sandra, Béhé, Martin, Boerman, Otto, Gotthardt, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150723/
https://www.ncbi.nlm.nih.gov/pubmed/29226686
http://dx.doi.org/10.1021/acs.molpharmaceut.7b00853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150723/
https://www.ncbi.nlm.nih.gov/pubmed/29226686
http://dx.doi.org/10.1021/acs.molpharmaceut.7b00853

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