Maintenance and Pharmacologic Targeting of ROR1 Protein Levels via UHRF1 in t(1;19) pre-B-ALL

Expression of the transmembrane pseudokinase ROR1 is required for survival of t(1;19)-pre-B-cell acute lymphoblastic leukemia (t(1;19) pre-B-ALL), chronic lymphocytic leukemia, and many solid tumors. However, targeting ROR1 with small-molecules has been challenging due to the absence of ROR1 kinase...

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Detalles Bibliográficos
Autores principales: Chow, Marilynn, Gao, Lina, MacManiman, Jason D., Bicocca, Vincent T., Chang, Bill H., Alumkal, Joshi J., Tyner, Jeffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150818/
https://www.ncbi.nlm.nih.gov/pubmed/29849118
http://dx.doi.org/10.1038/s41388-018-0299-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150818/
https://www.ncbi.nlm.nih.gov/pubmed/29849118
http://dx.doi.org/10.1038/s41388-018-0299-8

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